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Can transfusions of blood plasma slow down ageing or even rejuvenate people? Recent preclinical studies and experimental tests inspired by the technique known as parabiosis have aroused great media attention, although for now there is no clear evidence of their effectiveness. This line of research and the interest it is triggering testify to the prominent role played by the idea of combating the "natural" ageing process in the scientific and social agenda. While seeking to increase the duration of healthy living time may be considered a duty, it also raises ethical questions about how to pursue this goal. Specifically, therapies and techniques accessible only to a fraction of the population seem destined to exponentially increase social inequality and to produce undesirable consequences. In this article we address the issue precisely in the light of the prospected use of plasma for the rejuvenation of a small elite of people.In tracked and highly stratified educational systems, where educational reproduction is particularly strong, the chances of students to achieve more education than their parents did are truncated. Little is known, however, what may help students raised in lower-educated families to become upwardly mobile at the transition to upper-secondary education. In tracked educational systems, this transition is decisive for ultimate educational attainment across the life course. The study addresses this research gap by examining whether quality of social relationships (i.e., social capital) among students, parents, and teachers matters for student and teacher assessment of students' agentic capabilities (i.e., work habits) at age 15. If so, the question is whether these assessments help students become enrolled in high-status upper-secondary school tracks at age 18, thus achieving educational upward mobility. The analyses are based on 401 students from two cohorts in the German- and French-speaking parts of Switzerland, interviewed at the ages of 15 (T1) and 18 (T2) (60.35% females, Mage15 = 15.2, SDage15 = 0.2; 58.35% older cohort), including data collected by questionnaire from primary caregivers and teachers at student age of 15. The students come from families where highest parental education attainment is below the high-status academic or vocational baccalaureate in upper-secondary education. They may thus experience the opportunity to gain access to these high-status tracks at the transition to upper-secondary education. A structural equation model reveals the role of student assessment of their agentic capabilities and teacher assessment of these competencies in mediating the relation of social capital accrued at home and at school to educational upward mobility. This novel evidence on mechanisms of social advancement may be prone to inform interventions helping students from less-educated families to succeed in tracked and stratified educational systems.U.S. Latinx youth are growing up in an environment characterized by increased anti-immigrant policy and rhetoric, including experiences of discrimination. Given the salience of the school setting for youth's development, it is important to understand how experiences of discrimination by teachers and other adults at school, or school discrimination, relate to the emotional and behavioral adjustment of today's Latinx adolescents. Study participants include 547 Latinx adolescents selected at random from a large, suburban school district in Atlanta, Georgia (55.4% female; age M = 12.8, range = 11-16). Youth provided two time points of survey data spaced roughly 6 months apart during 2018 and 2019. Structural equation models (SEM) were used to test the main and interaction effects of school discrimination and parental support on later internalizing and externalizing symptoms. Multiple group SEM was used to investigate gender differences in pathways to adolescent adjustment. More school discrimination was related to more internalizing and externalizing symptoms at a later time point. Greater parental support was associated with fewer internalizing symptoms, but did not moderate associations between school discrimination and adolescent outcomes. Pathways to adolescent outcomes were similar for males and females. Study results suggest that discrimination by teachers and other adults at school is an important source of adversity potentially jeopardizing Latinx youth's emotional and behavioral adjustment. Future research is needed to identify factors that mitigate potentially harmful consequences of discrimination for Latinx adolescents.Nonmechanical fluid pumping principle has been developed utilizing the interactions of both the director [Formula see text] and velocity v fields and temperature T redistribution across a two-dimensional homogeneously-aligned nematic (HAN) microfluidic channel under the influence both of a heat flux [Formula see text] and the surface electric field E0, originating from the surface charge density [Formula see text]. The heat flux [Formula see text] is caused by the laser beam pulse focused on the channel's boundary, whereas the normally directed electric field is due to electric double layers, that is naturally created within the liquid crystal near a charged surface. Calculations, based upon the nonlinear extension of the classical Ericksen-Leslie theory, with accounting the entropy balance equation, show that due to the coupling between the [Formula see text] and [Formula see text], in the HAN microfluidic channel the vortical flow [Formula see text] may be excited. The direction and magnitude of [Formula see text] is influenced by [Formula see text] and E0, as well as by the thickness of the HAN microfluidic channel.Background Pure spinal epidural cavernous malformation (CM) is a rare hypervascular disease that is easily misinterpreted as other imaging-similar epidural lesions. The demographic characteristics, therapeutic strategies, and surgical outcomes associated with this vascular entity remains unclear. Methods A retrospective review of patients with pathologically proven, pure epidural CM from 2001 to 2018 was conducted. All data that included clinical manifestations, radiographic features, and treatment modalities were analyzed. Results Twenty-three consecutive patients with an average age of 51.5 ± 8.4 years old (range 38-70 years old) were included; of these, 52.2% were female patients. Clinical manifestation included chronic progressive nerve root disturbance syndrome in 7 patients (30.4%) and myelopathy in 16 patients (69.6%). [https://www.selleckchem.com/products/AC-220.html Quizartinib] The CM level was predominately thoracic (n = 14, 60.9%) or lumbar (n = 6, 26.1%), with the dorsal epidural space (n = 14, 60.9%) the most common site. The initial clinical diagnoses were schwannoma (n = 11, 52.