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The insights into the regulatory network underlying Zn deficiency responses and the perspective for further understandings of molecular regulation of Zn deficiency responses have been discussed. The understandings of the regulatory mechanisms will be important for improving Zn deficiency tolerance, Zn use efficiency, and Zn biofortification in plants.Predicting the consequences of recent changes in species distributional ranges is paramount. The trochid Phorcus sauciatus has recently colonised the Azores and is the only intertidal trochid in these islands. In this study we used experimental mesocosms to examine whether its addition to the remainder of the intertidal assemblage of grazers composed of littorinids and patellids affects the structure of epilithic biofilms growing on experimental plates. We also examined if its presence can compensate the loss of patellid limpets to simulate areas where these are chronically harvested. Results showed that when the native assemblage of grazers (littorinids and patellids) are present, the addition of P. sauciatus had little influence on the overall structure of epilithic biofilms. However, when patellids were absent, and in contrast to expectations, biofilm standing stock on experimental plates decreased significantly. Results suggest that patellids may negatively affect the foraging activities of P. sauciatus via interference competition and are further discussed in face of ecological knowledge of these organisms.Antibiotics use in poultry as a growth promoter leads to the propagation of antibiotic-resistant microorganisms and incorporation of drug residues in foods; therefore, it has been restricted in different countries. There is a global trend to limit the use of antibiotics in the animal products. Prevention of the antibiotics use in the poultry diets led to the reduction in the growth performance. Consequently, there is a high demand for natural substances that lead to the same growth enhancement and beneficially affect poultry health. These constituents play essential roles in regulating the normal physiological functions of animals including the protection from infectious ailments. Nutraceuticals administration resulted beneficial in both infectious and noninfectious diseases. Being the natural components of diet, they are compatible with it and do not pose risks associated with antibiotics or other drugs. Nutraceuticals are categorized as commercial additives obtained from natural products as an alternative feed supplement for the improvement of animal welfare. This group includes enzymes, synbiotics, phytobiotics, organic acids and polyunsaturated fatty acids. In the present review, the summary of various bioactive ingredients that act as nutraceuticals and their mode of action in growth promotion and elevation of the immune system has been presented.Fatigue-induced human error is a leading cause of accidents. The purpose of this exploratory study in China was to perform field tests to measure fatigue psychophysiological parameters, such as electrocardiography (ECG), electromyography (EMG), pulse, blood pressure, reaction time and vital capacity (VC), in miners in high-altitude and cold areas and to perform multi-feature information fusion and fatigue identification. Forty-five miners were randomly selected as subjects for a field test, and feature signals were extracted from 90 psychophysiological features as basic signals for fatigue analysis. Fatigue sensitivity indices were obtained by Pearson correlation analysis, t-test and receiver operating characteristic (ROC) curve performance evaluation. The ECG time-domain, ECG frequency-domain, EMG, VC, systolic blood pressure (SBP), and pulse were significantly different after miner fatigue. The support vector machine (SVM) and random forest (RF) techniques were used to classify and identify fatigue by information fusion and factor combination. The optimal fatigue classification factors were ECG-FD (CV Accuracy = 85.0%) and EMG (CV Accuracy = 90.0%). The optimal combination of factors was ECG-TD + ECG-FD + EMG (CV accuracy = 80.0%). Furthermore, SVM machine learning had a good recognition effect. This study shows that SVM and RF can effectively identify miner fatigue based on fatigue-related factor combinations. ECG-FD and EMG are the best indicators of fatigue, and the best performance and robustness are obtained with three-factor combination classification. This study on miner fatigue identification provides a reference for research on clinical medicine and the identification of human fatigue under high-altitude, cold and low-oxygen conditions.Treatment and prevention of cardiovascular diseases often rely on Electrocardiogram (ECG) interpretation. [https://www.selleckchem.com/products/Triciribine.html API-2 order] Dependent on the physician's variability, ECG interpretation is subjective and prone to errors. Machine learning models are often developed and used to support doctors; however, their lack of interpretability stands as one of the main drawbacks of their widespread operation. This paper focuses on an Explainable Artificial Intelligence (XAI) solution to make heartbeat classification more explainable using several state-of-the-art model-agnostic methods. We introduce a high-level conceptual framework for explainable time series and propose an original method that adds temporal dependency between time samples using the time series' derivative. The results were validated in the MIT-BIH arrhythmia dataset we performed a performance's analysis to evaluate whether the explanations fit the model's behaviour; and employed the 1-D Jaccard's index to compare the subsequences extracted from an interpretable model and the XAI methods used. Our results show that the use of the raw signal and its derivative includes temporal dependency between samples to promote classification explanation. A small but informative user study concludes this study to evaluate the potential of the visual explanations produced by our original method for being adopted in real-world clinical settings, either as diagnostic aids or training resource.<br />Identification and repurposing of therapeutic and preventive strategies against COVID-19 are rapidly undergoing. Several medicinal plants from the Himalayan region have been traditionally used to treat various human disorders. Thus, in our current study, we intended to explore the potential ability of Himalayan medicinal plant (HMP) bioactives against COVID-19 using computational investigations.<br />Molecular docking was performed against six crucial targets involved in the replication and transmission of SARS-CoV-2. About forty-two HMP bioactives were analyzed against these targets for their binding energy, molecular interactions, inhibition constant, and biological pathway enrichment analysis. Pharmacological properties and potential biological functions of HMP bioactives were predicted using the ADMETlab and PASS webserver respectively.<br />Our current investigation has demonstrated that the bioactives of HMPs potentially act against COVID-19. Docking results showed that several HMP bioactives had a superior binding affinity with SARS-CoV-2 essential targets like 3CL<br />, PLpro, RdRp, helicase, spike protein, and human ACE2.