Covid19 still rife inside Iran

rify those policy and modeling choices and therefore lead to improved population health outcomes.The health benefit of a vegetarian diet is still under debate as it may result in a higher intake of some beneficial micronutrients, while others may be reduced, thus influencing various metabolic pathways and health-related biomarkers. This scoping review discusses inflammatory, oxidative and DNA damage status in vegetarians and vegans compared to omnivores. Most of the reviewed studies indicated favorable effects of a vegetarian diet on oxidative status compared to omnivores but did not clearly associate particular dietary habits to genome damage. The evidence on the effect of vegetarian diet on the inflammatory and immunological biomarkers is poor, which could at least partly be explained by methodological constraints such as small sample size, short duration of vegetarianism and inconsistent definitions of the omnivorous diet. The only inflammatory biomarker that seems to be associated with the vegetarian diet was inflammatory mediator C-reactive protein, which in several studies showed lower values in vegetarians as compared to omnivores. There were very few studies on immunological markers and the results on the difference between vegetarians and omnivores were inconclusive. Although several biomarkers involved in oxidative stress and inflammation showed a beneficial association with the vegetarian diet, further research in well-defined and sufficiently sized cohorts is needed to provide more evidence.
Diabetic Kidney Disease (DKD) is the leading cause of end-stage kidney disease. Despite optimal glycemic control and blood pressure management, progression to DKD cannot be halted in some patients. We aimed to find the association of modifiable and non-modifiable risk factors and comorbid conditions in patients with DKD.
Retrospective medical record review of adult patients with diabetes mellitus (DM) was performed who visited our internal medicine office between January 1, 2020 and December 31, 2020.
Among 728 patients with DM, 471 (64.7%) patients had DKD, and 257 (35.3%) patients were without DKD. Among the group of patients with DKD, the majority were in CKD stage G1A2 (34.6%), followed equally by G2A2 and G3aA1 (16.8% each). Mean age of the patients with DKD was significantly greater than the patients without DKD (69.4 years vs 62.2 years;
 < .001). For each unit increase in age, there was a 7.8% increase in the odds of DKD (95% CI 5.3-10.4;
 < .001). Women had 2.32 times greater odds of artery disease, gout, and osteoarthritis were also seen in patients with DKD.
In patients with diabetes, increasing age, female sex, and lack of moderate alcohol consumption were associated with increased odds of DKD. Higher frequencies of association of hypertension, hyperlipidemia, coronary artery disease, cerebrovascular accidents, congestive heart failure, carotid artery stenosis, aortic aneurysm, peripheral artery disease, gout, and osteoarthritis were also seen in patients with DKD.We map the available scientific literature on how and why victims of sexual violence use digital platforms in the aftermath of victimization. Twenty-four empirical studies on sexual victimization and online disclosure were identified by systematically searching Web of Science and PsycINFO, checking reference lists, and consulting authors about relevant publications. The literature on online disclosure of sexual victimization does not yield a coherent picture. International literature pays limited attention to the various components of online disclosure like the characteristics of victims who disclosure online and the characteristics of the disclosure messages. Most studies focused on motivations for and reactions to online disclosure. Victims of sexual violence disclose sexual victimization online to seek support for clarification and validation, unburdening, documenting, seeking justice, informing others, or commercial goals (individual-oriented disclosure) and to provide support, educate, and as a form of activism (other-oriented disclosure). Responses to online disclosure are predominantly positive. Negative responses are rare. This review provides a comprehensive overview of multidisciplinary empirical information and displays knowledge gaps in victimological research. Future research should use robust quantitative and/or qualitative designs with substantial sample sizes, comparing victims who do disclose their sexual victimization online to victims who do not and comparing disclosure on different online platforms to increase generalizability. Potential for online support is identified, in which online disclosure can serve as a relatively safe alternative to off-line disclosure. This offers points of intervention for assistance and victim support in facilitating the use of the internet for support for victims of sexual violence.
No evidence of disease activity (NEDA-3) is a patient-centric outcome increasingly used as the goal of multiple sclerosis treatment.
Determine treatment durability of cladribine tablets beyond 2 years considering the variable bridging interval of 0.1-116.0 weeks between CLARITY and CLARITY Extension.
Between CLARITY and CLARITY Extension, patients transitioned from cladribine tablets 3.5 mg/kg to placebo (CP3.5 group,
 = 98) or continued further treatment with cladribine tablets 3.5 mg/kg (CC7.0 group,
 = 186). Treatment assignment was randomized and blinded in both CLARITY and CLARITY Extension.
The 2-year NEDA-3 in CLARITY Extension (encompassing both years of CLARITY Extension) was 29.6% in the CP3.5 group and 32.8% in the CC7.0 group. There was no evidence that treatment effect differed with varying bridging intervals. For patients in the CP3.5 group with a bridging interval of ⩽48 weeks, 1 year NEDA-3 (the first year of CLARITY Extension) was 44.4% (28/63) compared with 31.4% (11/35) in patients with a bridging interval of >48 weeks.
Treatment with cladribine tablets in CLARITY, followed by either placebo or cladribine tablets in CLARITY Extension, produced sustained benefits for NEDA-3 and its constituent elements for a follow up period up to 6 years from CLARITY baseline.
Treatment with cladribine tablets in CLARITY, followed by either placebo or cladribine tablets in CLARITY Extension, produced sustained benefits for NEDA-3 and its constituent elements for a follow up period up to 6 years from CLARITY baseline.The effective implantation of the circular economy (CE) presents a great challenge to the industrial sectors, mostly in those of greater environmental impact, such as construction industry. In Brazil, this industry has been growing over the last 20 years; however, such growth was based on an extractivist economy without any consideration to the end of its products lifespan. Only in 2017, 45 million tonnes of construction and demolition waste were generated in the country. This paper presents the current context of public policies in the Brazilian construction industry and proposes initiatives to introduce principles of CE. An exploratory study was developed, and all the 45 references presented in Appendix A of the review paper of Benachio et al. were considered to draw new ideas. These ideas are related and compared to key points in Brazilian regulations. Twelve opportunities for the improvement are listed and organized by construction stages (planning and design, materials manufacturing, construction processes, use and demolition). The ones related to design and planning using Green building information modelling, and materials manufacturing with recycled waste are highlighted due to the existing actions, standards, and Federal legislation. It was found that some sectors and the government already have actions related to CE (based on the 3R principle), but still there are several initiatives needed for its effective implementation in the Brazilian construction industry.
Characteristics of primary APS (PAPS) in the youth population have never been studied. In contrast with children, pregnancy is genuinely relevant in the youth age, and understanding clinical characteristics of PAPS patients within this specific age stratum may also provide insights regarding the well-known risk of poor obstetric outcomes during the adolescence.
To evaluate clinical and laboratory characteristics of patients with youth-onset PAPS (15-24 years) and compare them with adult-onset PAPS (over 24 years old).
This was a cross-sectional study derived from two rheumatology outpatient clinics. Patients who fulfilled Sidney criteria and who were 15 years of age or older at disease onset were included. Secondary APS patients were excluded. We subdivided patients into two groups youth- (15-24 years) and adult-onset (over 24 years) and compared them regarding demographic characteristics, criteria and non-criteria manifestations, cardiovascular risk factors, and aPL status. For the pregnancy outcomes adeath (58.5% vs. 46.4% vs. 24.1%,
= 0.012) and premature delivery (35.8% vs. 19.0% vs. 10.3%,
= 0.016). Of note, all groups had a comparable number of pregnancies (2.81±2.52 vs 2.74±2.07,
= 0.899).
This study provides novel evidence that youth-onset PAPS presents a higher frequency of obstetric complications as its first manifestation, with an increased risk of fetal death and preterm delivery. Early recognition of this condition by obstetricians is essential to improve prognosis.
This study provides novel evidence that youth-onset PAPS presents a higher frequency of obstetric complications as its first manifestation, with an increased risk of fetal death and preterm delivery. Early recognition of this condition by obstetricians is essential to improve prognosis.This study aimed to evaluate the in vitro effect of aloe emodin, barbaloin and chrysophanol on growing and mature biofilms of Cryptococcus neoformans sensu stricto. The compounds were added at the moment of inducing biofilm growth or after growth for 72 h to evaluate their effects on growing and mature biofilms, respectively. Then, biofilm biomass was evaluated by crystal violet staining and metabolic activity by the XTT reduction assay. Morphological alterations were also evaluated by laser scanning confocal microscopy. Aloe emodin and barbaloin affected growing biofilms and disrupted mature biofilms, reducing metabolic activity by > 60% and biomass by > 70%. Chrysophanol only inhibited mature biofilms, but to a lesser extent. In conclusion, anthraquinones, especially aloe emodin and barbaloin, show a relevant effect against growing and mature biofilms of C. neoformans sensu stricto.
Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. HPV can cause genital warts and multiple types of cancers in females. HPV vaccination is recommended to youth age 11 or 12 years before sexual initiation to prevent onset of HPV-related diseases. selleck products For females who have not been vaccinated previously, catch-up vaccines are recommended through age 26. The extent to which catch-up vaccines are beneficial in terms of disease prevention and cost-effectiveness is questionable given that some women may have been exposed to HPV before receiving the catch-up vaccination. This study aims to examine whether the cutoff age of catch-up vaccination should be determined based on an individual woman's risk characteristic instead of a one-size-fits-all age 26.
We developed a microsimulation model to evaluate multiple clinical outcomes of HPV vaccination for different women based on a number of personal attributes. We modeled the impact of HPV vaccination at different ages on every woman and tracked her course of life to estimate the clinical outcomes that resulted from receiving vaccines.