Hormetic endoplasmic reticulum tension within hematopoietic stem cells

ving immunosuppressive therapy due to the high frequency of UTIs.
This study aims to evaluate smell and taste functions in patients with fibromyalgia syndrome (FMS) and the relationship between smell and taste functions, anxiety, depression, alexithymia, and quality of life (QoL).
This cross-sectional study included 30 patients with FMS (3 males, 27 females; mean age 46.0±8.5 years; range, 18 to 70 years) and 20 age- and sex-matched healthy participants (2 males, 18 females; mean age 45.7±10.0 years; range, 18 to 70 years). Fibromyalgia Impact Questionnaire (FIQ) was applied to FMS patients. Hamilton Anxiety Scale, Depression Scale, Toronto Alexithymia Scale, and EuroQol Questionnaire Five-Dimensions (EQ-5D) were applied to all participants. Sniffin' Sticks test was used for olfactory function analysis while taste strips were used for gustatory function analysis.
The FMS patients had higher anxiety, depression, and alexithymia while lower QoL scores. Olfactory and gustatory function test scores were lower in FMS patients. Total olfactory function scores were 25.96 and 36.40 for FMS and control groups, respectively. For taste function, they were 9.93 and 13.55, respectively. These scores were negatively correlated with anxiety, depression, and alexithymia scores whereas positively correlated with EQ-5D index score. There was no significant correlation with FIQ score.
Anxiety and depression are common symptoms of FMS. Patients with FMS had altered olfactory and gustatory functions and these impairments were correlated with their anxiety and depression. Further studies with larger sample sizes including functional magnetic resonance imaging evaluation should be performed.
Anxiety and depression are common symptoms of FMS. Patients with FMS had altered olfactory and gustatory functions and these impairments were correlated with their anxiety and depression. Further studies with larger sample sizes including functional magnetic resonance imaging evaluation should be performed.
This study aims to evaluate the effectiveness of two multidisciplinary fibromyalgia programs with different intensities.
In this retrospective real-world comparison of patient data, pre- and post-program datasets of Short Form 36 (SF36) and Fibromyalgia Impact Questionnaire (FIQ) were obtained from a total of 210 female patients in two fibromyalgia multidisciplinary day hospital programs including one intensive program with daily treatments summing up to 20 treatment days during four weeks (P20, n=70) versus a less intensive program with 12 treatment days during four weeks (P12, n=140).
Multiple subscales of SF36 and FIQ were improved in the pre-post comparison in both groups. In the comparison between the two groups, a statistically significantly higher improvement was found in the P20 group compared to the P12 group for the FIQ subscales of stiffness (p=0.001) and the number of days during which the patient felt "good" (p=0.007).
An intensive program of daily treatments and activity seems to be more effective in reducing fibromyalgia-associated stiffness and improving the number of days during which patients feel good than a less intensive program.
An intensive program of daily treatments and activity seems to be more effective in reducing fibromyalgia-associated stiffness and improving the number of days during which patients feel good than a less intensive program.
This study aims to assess the nailfold capillary changes in patients with systemic lupus erythematosus (SLE), particularly among those with Raynaud's phenomenon (RP), and the correlation between nailfold capillary changes and autoantibodies and disease activity.
A total of 85 patients (9 males, 76 females; median age 31 years; range, 15 to 58 years) with newly diagnosed SLE were selected between July 2016 and July 2018 from our hospital. Disease activity was scored by the SLE Disease Activity Index. Nailfold capillaroscopy (NFC) was performed in all patients.
Normal pattern, non-specific pattern, and scleroderma pattern were found in 13 (15.3%), 64 (75.3%), and eight (9.4%) patients, respectively. There was no significant difference between anti-double stranded deoxyribonucleic acid, anti-Smith antibodies, and low complements (all p>0.05), while significant differences of NFC pattern were found between low disease activity and high disease activity (p=0.002). RP was present in 31.7% of SLE patients, and the NFC findings in SLE patients with and without RP were significantly different in dilatation (81.5% vs. 14.0%).
The results of our study showed that capillary changes were very common in patients with SLE, which seem to associate with disease activity and RP condition.
The results of our study showed that capillary changes were very common in patients with SLE, which seem to associate with disease activity and RP condition.
This study aims to investigate the outcomes and risk factors associated with the progression of systolic pulmonary artery pressure (sPAP) in patients with systemic rheumatic diseases.
A total of 532 patients (73 males, 459 females; median age 49 years; interquartile range (IQR), 36 to 62 years) registered with the Registry of Pulmonary Hypertension Associated with Rheumatic Diseases were included. Selleck Deferoxamine Mortality curves were constructed using the Kaplan- Meier method and comparisons were performed using the log-rank test. A paired t-test was performed to evaluate the patients with markedly elevated sPAP between baseline and follow-up.
The average follow-up duration was 31 months (IQR, 9 to 60 months). Of the patients, 196 had follow-up echocardiographs at least one year later. We defined the sPAP over 60 mmHg as markedly elevated. Patients in the increased sPAP above 60 mmHg at follow-up and persistently markedly elevated sPAP were associated with worse outcomes in all-cause mortality and pulmonary arterial h diseases.
This study aims to investigate lymphoproliferation, cytokine production, and intracellular signaling molecules in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals and rheumatoid arthritis (RA) patients to understand the extent of the involvement of these pathways in the pathogenesis of RA.
The study included 65 participants (29 males, 36 females; mean age 51.8±10.3 years; range, 37 to 71 years) who were categorized into four groups as healthy males (n=22, mean age 49.8±10.6 years; range, 39 to 65 years), male RA patients (n=7, mean age 51.8±13.9 years; range, 37 to 68 years), healthy females (n=20, mean age 53.7±8.8 years; range, 42 to 67 years), and female RA patients (n=16, mean age 52.9±10.4 years; range, 40 to 71 years). PBMCs were collected from the participants and analyzed for Concanavalin A (Con A)-induced lymphoproliferation using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, cytokine production, and phospho-signal transducer and activator of transcription 3 (p-STAT-3), phospho-extracellular-signal-regulated kinase (p-ERK), phospho-cAMP response element binding (p-CREB), and phospho-protein kinase B expressions using enzyme-linked immunosorbent assay.