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2341, 46.7953, 60.5925, and 61.4862, respectively. The proposed segmentation technique can attain a high PSNR (>40db) value at a threshold value equal to 0.1. Also proposed approach attains good precision, recall, and SSIM values. The lowest MSE values using proposed segmentation techniques are 0.0454, 0.0351, 0.0924, and 0.0271 individually. The AD, NK, SC, NAE, and LMSE values for the implemented approach are low, showing that the segmented image's quality is very good. Thus, the proposed model performed better compared to other methods.
This study demonstrates the possibility of detecting tumors on mammograms with high accuracy (more than 72%) using neural networks and studies the characteristics of machine learning models for improving their efficiency.
We have proposed image preprocessing methods that enable high classification accuracy, as well as methods of increasing the training set and balancing the distribution of diagnostic classes when the training set is small. The classification has been done for the following four diagnostic classes dysplasia, pre-cancer state (ductal carcinoma in situ), cancer state (invasive carcinoma), and benign tumor.
We have conducted experiments to compare different models based on convolution neural networks and proposed methods for estimating the model quality. We have obtained a base model that can be used to make recommendations to establish a diagnosis. We have studied the characteristics of the base model and identified promising directions of modification for further improving the quality estimates.
We have conducted experiments to compare different models based on convolution neural networks and proposed methods for estimating the model quality. We have obtained a base model that can be used to make recommendations to establish a diagnosis. We have studied the characteristics of the base model and identified promising directions of modification for further improving the quality estimates.
Takayasu's arteritis (TA) is a large vessel vasculitis with diverse clinical presentations and arterial vascular bed involvement. It is characterized by chronic, nonspecific inflammation of all layers of the vessel wall, which results in stenosis, occlusion, dilatation, or aneurysm formation in the involved blood vessels.
The study included 36 patients of TA. All patients fulfilled the modified Ishikawa's diagnostic criteria for TA. All patients were evaluated for clinical presentation, angiographic findings, and severity of the disease. The disease activity was assessed based on Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and also by CT angiography (CTA)/Magnetic resonance angiography (MRA) imaging. The angiographic types were classified based on the International TA Conference in Tokyo, 1994 angiographic classification.
A total of 36 patients were included in the study, 86% were females and a mean age of 21.6 years. Hypertension (78%) was the most common clinical presentation. Ty.Tuberculosis (TB) is an infectious disease and is declared a global health issue by the World Health Organization in 1993. Due to the complex pathophysiology of Mycobacterium tuberculosis, it remains a global threat. This article reviews the conventional diagnostic modalities for tuberculosis, their limitations to detect latent TB, multiple drug-resistant TB, human immunodeficiency virus co-infected TB lesions, and TB in children. Moreover, this review illustrates the importance of nuclear medicine imaging for early, non-invasive diagnosis of TB to detect disease stages and monitor therapy response. Currently, single-photon emission computed tomography and positron emission tomography with their specific radionuclides have been extensively used for a thorough assessment of TB.Painful diabetic peripheral neuropathy (painful-DPN) is a highly prevalent and disabling condition, affecting up to one-third of patients with diabetes. This condition can have a profound impact, resulting in a low quality of life, disruption of employment, impaired sleep, and poor mental health with an excess of depression and anxiety. The management of painful-DPN poses a great challenge. Unfortunately, there are currently no Food and Drug Administration (USA) approved disease-modifying treatments for diabetic peripheral neuropathy (DPN) as trials of putative pathogenetic treatments have failed at phase 3 clinical trial stage. Therefore, the focus of managing painful-DPN other than improving glycaemic control and cardiovascular risk factor modification is treating symptoms. The recommended treatments based on expert international consensus for painful-DPN have remained essentially unchanged for the last decade. Both the serotonin re-uptake inhibitor (SNRI) duloxetine and α2δ ligand pregabalin have the most s to assess novel therapeutic agents, optimal combination therapy, and existing agents to determine which are the most effective for the treatment of painful-DPN. Proteasome inhibitor This article reviews the evidence for the treatment of painful-DPN, including emerging treatment strategies, such as novel compounds and stratification of patients according to individual characteristics, (e.g., pain phenotype, neuroimaging, and genotype) to improve treatment responses.
Hepatitis C virus (HCV) acts in host as a complicated mixture of related variants with the potency to genetically escape host immune responses. Direct acting antivirals (DAAs) have been approved for HCV treatment with shorter duration, better cure rates and lower side effects. However, naturally occurring resistance associated substitutions(RASs) make some obstacles to this antiviral therapy success.
In this study, we aimed at determination of the naturally occurring NS3/4A RASs in HCV/human immunodeficiency virus (HIV)infected patients.
A total of 120 DAA-naïve HCV-HIV co-infected patients were included. HCV NS3/4Agenome region was amplified with PCR and mutation analysis was performed by Sanger sequencing technique. The amino acid sequence diversity of the region wasanalyzed using geno2pheno HCV.
Phylogenetic analysis showed that 73 cases were infected by 3a and 47 subjects by subtype1a. The overall RASs among studied subjects wereobserved in 6 (5%) individuals from 120 studied cases who were infected with HCV 1a.