Tau seeding throughout chronic distressing encephalopathy parallels ailment intensity

All autonomy-hindering scopes for physiotherapy practice in African countries should be repealed and amended accordingly.
A clear scope shall assist with protecting the public and clinical practice and clearly states 'what physiotherapy is and what it is not'.
A clear scope shall assist with protecting the public and clinical practice and clearly states 'what physiotherapy is and what it is not'.
Work-related musculoskeletal disorders (WMSDs) are a global public concern for health and social-care systems, as well as individuals. They are the second-most prevalent cause of disability globally.
The primary objective was to determine the prevalence of WMSDs amongst flower farm workers. The secondary objective was to determine the association between the socio-demographic characteristics and the presence of WMSDs in the previous 12-month period.
A cross-sectional descriptive study was conducted. A sample of 270 participants was drawn from 897 farm workers. Quantitative data related to musculoskeletal disorders were collected using the Nordic Musculoskeletal Questionnaire (NMQ). Descriptive statistics were undertaken using frequencies and percentages. Inferential statistics were analysed using a chi-squared test (X
) based on an alpha level of
< 0.05.
A total of 184 (68.1%) respondents reported musculoskeletal discomfort. Amongst the 184 respondents, 178 were performing general farm work. Most 103 (38.1%) of the WMSDs were reported in the lower back. There was a strong association between job designation as a general worker (
= 0.016), an older age (
= 0.027) and having worked for a long time as a farm worker (
= 0.041) and WMSDs.
Flower farm workers in Kenya were found to be heavily burdened by WMSDs. Furthermore, the job designation, older age, as well as having worked for a long time, predisposes workers to the risk of developing WMSDs.
The high prevalence of WMSDs necessitates policy reform in the flower farm industry.
The high prevalence of WMSDs necessitates policy reform in the flower farm industry.
Patient safety is a part of healthcare that is not only important in the delivery of healthcare but also in the training of healthcare professionals. It is a key component of physiotherapy treatment which, when underrated, can result in more harm than good.
To determine the level of knowledge, perception and attitude of patient safety amongst physiotherapy students.
Eighty clinical year physiotherapy students from the University of Ghana and the University of Health and Allied Sciences were recruited for this cross-sectional study. find more Data were obtained using the World Health Organization Medical School Curricular Guide for Patient Safety questionnaire. Pearson Chi-square was used to test for association between the level of study of participants and their knowledge on patient safety.
Of the eighty (80) respondents, there were 41 women (52.1%) and 39 men (48.8%) in our study. Majority of the respondents (97.5%) had a moderate level of knowledge on patient safety. There was no significant association between the level of study and knowledge of clinical year physiotherapy students on patient safety (
= 0.712).
Clinical year physiotherapy students in Ghana have a moderate level of knowledge on the concept of patient safety. Restructuring of the physiotherapy curriculum to specifically cover the concept of patient safety would be beneficial to its promotion in the healthcare system.
The outcomes of our study may motivate physiotherapy students to put in additional effort that could facilitate the translation of positive attitudes that have been shown to be effective in reducing errors and promoting patient safety.
The outcomes of our study may motivate physiotherapy students to put in additional effort that could facilitate the translation of positive attitudes that have been shown to be effective in reducing errors and promoting patient safety.
Anterior knee pain (AKP) commonly affects both physically active and sedentary individuals and the aetiology is unknown. Altered joint position sense (JPS) impacts accurate motor action and knee joint stability. It is unclear whether people with AKP have altered JPS.
The aim of our study was to investigate JPS in the knees of individuals with AKP.
A descriptive cross-sectional study measured JPS in 25 participants with unilateral or bilateral AKP. JPS was measured using active JPS testing during single leg squat (SLS) and active knee extension (AKE) in sitting. Target angles (TA) were self-determined based on each participant's capabilities. The absolute error (AE) was the main outcome measure. Impaired JPS was classified as an AE equal to or greater than five degrees.
There were no significant differences in JPS when comparing the affected and unaffected knees in participants with AKP (
> 0.05). However, a subgroup of participants with altered knee JPS was identified. There was a tendency towards greater knee flexion in the TAs of knees without AKP.
Our results showed that JPS is not significantly more impaired in knees with AKP compared with knees without AKP in a group of individuals with AKP. link2 A subgroup with altered JPS in knees with and without AKP was identified. This finding could be because of compensatory gait patterns and the precision of the Vicon 3D motion analysis system.
Joint position sense should be assessed bilaterally in individuals with AKP.
Joint position sense should be assessed bilaterally in individuals with AKP.
Several screening tools are available for use in a clinical setting to predict injury. However, there is a lack of evidence regarding the accuracy of these tools to predict soccer-specific injuries.
The purpose of this systematic literature review was to determine the psychometric properties or accuracy of screening tools for common soccer injuries.
A systematic review of diagnostic test accuracy was undertaken based on the Joanna Briggs Institute (JBI) procedure for conducting systematic reviews. Databases such as SPORT Discus, Cinahl, Medline, Science Direct, PubMed and grey literature were searched in order to access suitable studies.
A total of 10 studies were included for the analysis - three were analysed quantitatively whilst the remaining seven were analysed qualitatively. The screening tools were of high reliability, sensitivity and specificity (calculated as intraclass correlation coefficient [ICC] (0.68 95% confidence interval [CI] 0.52-0.84 and 0.64 95% CI 0.61-0.66, respectively).
The screening tools assessed for the prediction of common soccer injuries that emerged from this systematic review include the Functional Movement Screening (FMS™), the Landing Error Scoring System (LESS), the Tuck Jump Assessment, the Soccer Injury Movement Screening (SIMS) and the conventional hamstrings to quadriceps ratio; all with good evidence of predicting common soccer injuries. These tools were of high sensitivity and specificity thus reliable for soccer screening.
The validity of these tools is acceptable and therefore the authors recommend that these tools be included in an injury prevention programme for soccer players.
The validity of these tools is acceptable and therefore the authors recommend that these tools be included in an injury prevention programme for soccer players.
Across the lifespan, people with spinal cord injury (SCI) may experience preventable secondary health conditions (SHCs) such as pressures sores, muscle spasms and urinary tract infections (UTIs). Some factors influencing prevention of SHCs include social support, poor access to care and the prevention style of individuals. There is limited research on these factors.
To explore personal factors influencing the prevention of SHCs in people with SCI.
An explorative qualitative study included participants recruited in an outpatient department at a rehabilitation hospital. Semi-structured interviews were conducted with patients with SCI. Interviews were transcribed verbatim. Data analysis was conducted using content analysis.
Seventeen individuals with SCI were interviewed. From the interview analysis, six personal factors were identified, namely, socio-economic status; mental well-being (forgetfulness, beliefs, attitude); lack of knowledge of SHCs and prevention; lifestyle choices and practising prevention care; patient activation (self-management, problem-solving, resilience, self-awareness, help-seeking behaviour) and owning an appropriate assistive device.
Socio-economic status, mental well-being, knowledge of SHCs and prevention care, behaviour patterns, patient activation and owning an appropriate assistive device can influence prevention of SHCs. To enhance patient-oriented care, a model of care for people with SCI should consider these factors when developing prevention strategies. Future research could look into identifying environmental factors that influence the prevention of SHCs in people with SCI.
Tailored prevention strategies need to be developed, health professionals must ask patients about individual factors that may be barriers or facilitators to preventing secondary health conditions.
Tailored prevention strategies need to be developed, health professionals must ask patients about individual factors that may be barriers or facilitators to preventing secondary health conditions.
COVID-19 has currently emerged as the major global pandemic affecting the lives of people across the globe. It broke out from Wuhan Province of China, first reported to WHO on 31
December 2019 as "Pneumonia of unknown cause". Over time more people were infected with this virus, and the only tactic to ensure safety was to take precautionary measures due to the lack of any effective treatment or vaccines. As a result of unavailability of desired efficacy for previously repurposed drugs, exploring novel scaffolds against the virus has become the need of the hour.
In the present study, 23 new annomontine analogues were designed representing
-Carboline based scaffolds. link3 A hypothesis on its role as an effective ligand was laid for target-specific binding in SARS-CoV-2. These molecules were used for molecular docking analysis against the multiple possible drug targets using the Maestro Interface. To ensure the drug safety of these molecules ADME/Tox analysis was also performed.
The molecular docking analysiomontine based - β- Carboline derivatives as a potential drug candidate against COVID-19.Background Metastatic breast cancer cells recruit macrophages (metastasis-associated macrophages, or MAMs) to facilitate their seeding, survival and outgrowth. However, a comprehensive understanding of the gene expression program in MAMs and how this program contributes to metastasis remain elusive. Methods We compared the transcriptomes of MAMs recruited to lung metastases and resident alveolar macrophages (RAMs) and identified a large variety of differentially expressed genes and their associated signaling pathways. Some of the changes were validated using qRT-PCR and immunofluorescence. To probe the functional relevance to metastatic growth, a gene-targeting mouse model of female mice in the C57BL6/J background was used to study allograft inflammatory factor 1 (AIF1, also known as ionized calcium-binding adapter molecule 1 or IBA1). Results Interferon signaling is one of the most activated pathways in MAMs, with strong upregulation of multiple components of the pathway and a significant enrichment for the gene signatures of interferon-alpha-treated human macrophages.