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Pragmatic trials are trials designed to inform the real-world practice of clinical. They are typically characterized by a focus on the practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of standard equipment.
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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for pragmatic trials to be reliable and reduce bias in results is also essential. Too much heterogeneity, however, can cause problems with the trial design.
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Pragmatic Play has gained a reputation for offering high-quality games and a superior user experience. Its software is accessible on mobile devices and in multiple languages. Despite its relative youth it has already established itself as a top casino gaming platform. Wolves is one of its latest releases, a 5-reel slot machine that has a high RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually requested by practitioners and policy makers to guide their decision-making. They can also be used to determine the cause-effect relationship of an intervention and its results. However, they should not, be used to replace explanatory studies.
The pragmatism idea is controversial, and there are questions regarding whether pragmatic trials could replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the elements of a practical study that includes recruitment, design, implementation of the intervention and its follow-up.
There is an encouraging trend in the number of pragmatic trials published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatics. It is important to note, however, that the majority were conducted in primary-care settings.