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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are often focused on the practical aspects of the study design, such as the recruitment and consent process, adherence, and the use of routinely available equipment.
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Pragmatic is a software development company that offers a wide range of casino games on online gambling platforms. Pragmatic's iGaming software is used by top operators and land based casinos. The company provides front-end site design tools, analysis tools and promotions, marketing, security, payment systems, customer support and bug-reporting. Additionally, the company offers its players a safe and secure environment with high-quality graphics and gameplay.
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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity, and it also helps to reduce the chance of bias in the results. However too much heterogeneity could lead to problems with the design of the trial.
Pragmatic Play is also a major player on the live casino market, offering an extensive selection of classic table games such as Blackjack and Roulette in various variations. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gaming experience as well a full variety of betting options via virtual. The company also hosts a variety of game shows that make online gambling fun and interactive. Some of these shows are broadcast live, while others feature famous personalities in the industry.
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Pragmatic Play, a relatively new player in the field of casinos online, has earned recognition for its mobile-friendly slot machines. Their games are optimised for mobile devices and operate on HTML5 technology. They're also endorsed by reputable gaming authorities to ensure transparency and fairness. This is a great signal for players since it indicates that the games have been tested and verified to ensure randomness and impartiality of each round.
Pragmatic Play offers not only mobile-friendly slot machines as well as live casino and table games. The company is licensed and is regulated by various regulatory bodies that include the Malta Gaming Authority and UK Gambling Commission. The games offered by the company are protected by high-end encryption and its security team is on hand to help players with any issues.
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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They are also a good method to determine the causality between an intervention and its outcomes. However, they should not be used to substitute for explanatory studies.
The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate a physiological or clinical hypothesis, and pragmatic trials, which guide policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a practical study that includes the recruitment, design, and delivery of the intervention and its follow-up.
The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note that the majority of studies were conducted in primary-care settings.