Advance of the Kid Choledocholithiasis Conjecture Model

Patients undergoing combined CPI-chemotherapy received a lower median biologically effective dose of SBRT than those undergoing CPI monotherapy (43.2 vs. 60Gy), but had a higher rate of radiation-induced toxicity (56% vs. 32%, P < .01). The best systemic ORR was 53%, with 20.5% stable disease and 26.5% progressive disease. Fifteen patients underwent a subsequent course of SBRT based on their response, among which 3 (20%) had progression-free intervals of 12, 16, and 10 months thereafter.
Addition of SBRT to CPI immunotherapy (with/without chemotherapy) is safe. The favorable systemic response observed warrants further assessment with a randomized trial.
Addition of SBRT to CPI immunotherapy (with/without chemotherapy) is safe. The favorable systemic response observed warrants further assessment with a randomized trial.Designated under the name of chromoanagenesis, the phenomena of chromothripsis, chromanasynthesis and chromoplexy constitute new types of complex rearrangements, including many genomic alterations localized on a few chromosomal regions, and whose discovery over the last decade has changed our perception about the formation of chromosomal abnormalities and their etiology. Although exhibiting specific features, these new catastrophic mechanisms generally occur within a single cell cycle and their emergence is closely linked to genomic instability. Various non-exclusive exogenous or cellular mechanisms capable of generating chromoanagenesis have been evoked. However, recent experimental data shed light on 2 major processes, which following a defect in the mitotic segregation of chromosomes, can generate a cascade of cellular events leading to chromoanagenesis. These mechanisms are the formation of micronuclei integrating isolated chromosomal material, and the occurrence of chromatin bridges around chromosomal material resulting from telomeric fusions. In both cases, the cellular and molecular mechanisms of fragmentation, repair and transmission of damaged chromosomal material are consistent with the features of chromoanagenesis-related complex chromosomal rearrangements. In this review, we introduce each type of chromoanagenesis, and describe the experimental models that have allowed to validate the existence of chromoanagenesis events and to better understand their cellular mechanisms of formation and transmission, as well as their impact on the stability and the plasticity of the genome.
Many individuals have had dreams accurately describing their own health problems before any medical diagnosis. Some have even had accurate dreams depicting the health problems of others.
To examine the characteristics of dreams of a practicing medical intuitive. It was hoped to describe in more detail, the differences between her health related dreams and her "normal" or non-health dreams. Her health dreams were all chosen because they successfully described a malady before it was diagnosed by any medical professional.
Ninety dreams (30 normal, 30 self health related, 30 for others) were content analyzed using the online Hall-Van de Castle Content Analysis scoring system.
The non-health dreams of the dreamer were significantly longer than the two samples of health dreams (p < .001). The two sets of health dreams did not differ in report length. In terms of content, the health dreams, either for the dreamer herself, or for a patient were composed of precise literal references and descriptions about the nature of the health problem. selleck compound While there was also some symbolism in a few of these dreams, the symbols were considered very easy to interpret.
While these dreams were all collected from a very experienced, talented medical intuitive, their structure may be similar to the dreams of many individuals. It would be of value to collect and examine the dreams from a number of individuals that have had health dreams in the course of solving their own health problems.
While these dreams were all collected from a very experienced, talented medical intuitive, their structure may be similar to the dreams of many individuals. It would be of value to collect and examine the dreams from a number of individuals that have had health dreams in the course of solving their own health problems.
This paper articulates and problematises the 'exceptionalism' in the way shabu (crystal methamphetamine) is framed in political and popular discourse in the Philippines, and how these framings have informed and enabled the drug regime in the country, creating a 'state of exception' and justifying the killing-whether extrajudicially or through the death penalty-of people associated with the particular drug.
Two case studies are presented in this paper to demonstrate how political and civil society actors treat shabu, drawing on official statements, journalistic reportage, and published articles from various sources as empirical material, and using a problematisation framework to guide analysis.
'Methamphetamine exceptionalism' pervades public discourse in the Philippines, creating a social and political environment that is permissive for, if not outright supportive of, draconian measures particular toward people associated with shabu. Such views are rooted in the perception that shabu is especially dangerous as opposed to other drugs, thereby posing an exceptional threat to the body politic.
This paper underscores the importance of nuance in constructing and interrogating the objects of drug policy, given that different drugs are treated differently. Policy and communication interventions must therefore specifically address the ways in which shabu has been framed to justify not only Duterte's deadly drug war, but other such wars throughout the region.
This paper underscores the importance of nuance in constructing and interrogating the objects of drug policy, given that different drugs are treated differently. Policy and communication interventions must therefore specifically address the ways in which shabu has been framed to justify not only Duterte's deadly drug war, but other such wars throughout the region.
The purpose of the pilot study was to determine if an educational program on opioid safety and disposal during a preoperative joint replacement class would increase the frequency of disposal of unused opioids with a disposal pouch at the end of the episode of care in patients undergoing joint replacement. A secondary aim was to quantify the milligrams of morphine equivalents prescribed, used, disposed, and remaining in joint replacement patients.
The study design is quasi-experimental.
A medication disposal pouch was provided to all study subjects preoperatively. A 2-minute opioid safety and disposal instruction and demonstration of the use of the disposal pouch was performed at a weekly preoperative joint replacement class which was optional for subjects to attend. A nine-question phone survey was then administered to subjects postoperatively.
One hundred and four patients completed the study survey. Of the subjects who attended the class and had opioids remaining, 74% disposed of their opioids compared with 36% that did not attend the class (p=.