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However, with a high-riding VA, the entry point needs to be shifted medially. C1 lateral mass screws were inserted according to the standard technique and fixed to C2 screws with rods. Postoperatively, the patient improved and radiology showed satisfactory reduction with good flow across the VA on angiography. There is a minimal risk of arterial injury/spasm due to its handling. selleck chemicals llc Nevertheless, the benefit of a strong construct clearly outweighs this risk. Alternatively, one may insert a C2 laminar screw. However, the biomechanical considerations are better with the C2 pedicle screws and the overall construct may be not ideal as the fixation is away from the C1-C2 joint.3-5,9.
The subthalamic nucleus (STN) is an important target during deep brain stimulation (DBS). Accurate lead placement is integral to achieving satisfactory clinical outcomes; however, the STN remains a structure whose visualization is highly variable with borders often difficult to define. We aimed to develop an objective method of evaluating the visibility of the STN on preoperative magnetic resonance imaging (MRI) to standardize future comparative assessments between imaging protocols and patient-specific parameters.
An imaging study of 64 prospectively collected patients undergoing bilateral DBS of the STN for various movement disorders was performed with institutional approval. MRI scans were acquired using a uniform protocol involving general anesthesia, cranial fixation in a Leksell stereotactic frame, and long acquisition times using a 3T MRI scanner. The images were analyzed using the iPlan Stereotaxy, version 2.6, workstation. High-resolution T2-weighted axial sections were evaluated, and the voxel vn head volume and STN visibility was identified.
Our proposed statistical model allows for standardized examination of the visibility of the STN border for DBS and has potential for both clinical and academic applications.
Our proposed statistical model allows for standardized examination of the visibility of the STN border for DBS and has potential for both clinical and academic applications.
The purpose of this study was to test the application of diffusion tensor imaging (DTI) in patients with hemifacial spasm (HFS), to make more accurate diagnoses before surgery and to judge the degree of recovery more accurately after surgical microvascular decompression. To our knowledge, this is the first study to test the validity of DTI for diagnosis and postsurgical evaluation of HFS.
We included 40 patients with HFS who underwent DTI scanning before microvascular decompression. They were followed up with DTI 6 months and 1 year after surgery. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were obtained and compared.
In patients with HFS, the FA value of the affected side (mean FA, 0.46 ± 0.03) was significantly lower than that of the healthy side (mean FA, 0.43 ± 0.04; P < 0.05), and the ADC value of the affected side (mean FA, 1.60 ± 0.14) was significantly higher than that of the healthy side (mean ADC, 1.50 ± 0.12; P < 0.05). Compared with those before surgery, the FA values of both follow-up patients increased significantly, whereas their ADC values decreased significantly.
The use of DTI improves diagnosis and treatment of HFS.
The use of DTI improves diagnosis and treatment of HFS.The sarcomere is the functional unit of cardiac muscle, essential for normal heart function. To date, it has not been possible to study, in real time, thin filament-based activation dynamics in live cardiac muscle. We report here results from a cardiac troponin C (TnC) FRET-based biosensor integrated into the cardiac sarcomere via stoichiometric replacement of endogenous TnC. The TnC biosensor provides, for the first time, evidence of multiple thin filament activating ligands, including troponin I interfacing with TnC and cycling myosin, during a cardiac twitch. Results show that the TnC FRET biosensor transient significantly precedes that of peak twitch force. Using small molecules and genetic modifiers known to alter sarcomere activation, independently of the intracellular Ca2+ transient, the data show that the TnC biosensor detects significant effects of the troponin I switch domain as a sarcomere-activating ligand. Interestingly, the TnC biosensor also detected the effects of load-dependent altered myosin cycling, as shown by a significant delay in TnC biosensor transient inactivation during the isometric twitch. In addition, the TnC biosensor detected the effects of myosin as an activating ligand during the twitch by using a small molecule that directly alters cross-bridge cycling, independently of the intracellular Ca2+ transient. Collectively, these results aid in illuminating the basis of cardiac muscle contractile activation with implications for gene, protein, and small molecule-based strategies designed to target the sarcomere in regulating beat-to-beat heart performance in health and disease.Pain is the most debilitating symptom in juvenile idiopathic arthritis. As pain correlates poorly to the extent of joint pathology, therapies that control joint inflammation are often inadequate as analgesics. We test the hypothesis that juvenile joint inflammation leads to sensitisation of nociceptive circuits in the central nervous system, which is maintained by cytokine expression in the spinal cord. Here, transient joint inflammation was induced in postnatal day (P)21 and P40 male Sprague-Dawley rats with a single intra-articular ankle injection of complete Freund's adjuvant. Hindpaw mechanical pain sensitivity was assessed using von Frey hair and weight bearing tests. Spinal neuron activity was measured using in vivo extracellular recording and immunohistochemistry. Joint and spinal dorsal horn TNFα, IL1β and IL6 protein expression was quantified using western blotting. We observed greater mechanical hyperalgesia following joint inflammation in P21 compared to P40 rats, despite comparable duration of swelling and joint inflammatory cytokine levels. This is mirrored by spinal neuron hypersensitivity, which also outlasted the duration of active joint inflammation. The cytokine profile in the spinal cord differed at the two ages prolonged upregulation of spinal IL6 was observed in P21, but not P40 rats. Finally, spinal application of anti-IL-6 antibody (30 ng) reduced the mechanical hyperalgesia and neuronal activation. Our results indicate that persistent upregulation of pro-inflammatory cytokines in the spinal dorsal horn is associated with neuronal sensitisation and mechanical hyperalgesia in juvenile rats, beyond the progress of joint pathology. In addition, we provide proof of concept that spinal IL6 is a key target for treating persistent pain in JIA.