Edmond Atomic 19202021

The circular structure of values has been verified mostly at a between-person level and on measures of general value preferences. In this manuscript, we argue that it is a simplification that neglected significant aspects of the value structures and distinguish four different types of structures (a) between-person structure of value traits, (b) within-person structure of value traits, (c) between-person structure of value states, and (d) within-person structure of value states. We argue that the within-person structure of value states addresses the circular structure of values most accurately.
To compare all four structures, we collected three partially dependent samples (N
=449, N
=293, N
=218) of adults (age 17-57, M=24). At three time points, separated by 5-7weeks, respondents completed a questionnaire measure (Portrait Values Questionnaire-Revised [PVQ-RR]) of value preferences (value traits) and reported the importance of values in their everyday actions (value states) for 1week in an experience sampling study.
The four types of value structures were stable over time. Selleckchem FIIN-2 All four were also consistent with Schwartz's value model to some degree, but at the same time, there were some deviations.
It is important to distinguish four types of value structures and be aware of their different interpretations that we outlined in this paper.
It is important to distinguish four types of value structures and be aware of their different interpretations that we outlined in this paper.
Determine contemporary incremental increases in healthcare expenditures and utilization associated with chronic rhinosinusitis (CRS).
Cross-sectional analysis of national health care survey data.
Patients reporting a diagnosis of CRS were extracted from the 2018 Medical Expenditure Panel Survey medical conditions file and linked to the consolidated expenditures file. CRS patients were then compared to non-CRS patients determining differences in healthcare utilization for office visits, emergency facility visits, and prescriptions filled as well as differences in total healthcare costs, office-based costs, prescription medication costs, and self-expenditures using demographically and comorbidity adjusted multivariate models. Results were compared to 2007, adjusted for inflation.
An estimated 7.28 ± 0.36 million adult patients reported CRS in 2018 (3.0 ± 0.1% of the adult U.S. population). The additional incremental healthcare utilizations associated with CRS relative to non-CRS patients for office visits, emergency facility visits, and number of prescriptions filled were 4.2 ± 0.6, 0.10 ± 0.03, and 6.0 ± 0.9, respectively (all P ≤ .003). Similarly, additional incremental healthcare expenditures associated with CRS for total health care expenses, office-based visit expenditures, prescription expenditures, and self-expenditures were $1,983 ± 569, $772 ± 139, $678 ± 213, and $68 ± 17, respectively (all P ≤ .002). Increases in total (+$1,062) and office based expenditures (+$360) compared to 2007 were significant.
CRS continues to be associated with a substantial incremental increase in healthcare utilization and expenditures. These expenditures have significantly outpaced inflation expected increases. The national healthcare costs of CRS have increased to an estimated $14.4 billion per year.
3 Laryngoscope, 1312169-2172, 2021.
3 Laryngoscope, 1312169-2172, 2021.
Fatigue is a common and expected side effect of cancer treatment. However, the majority of studies to date have focused on average levels of fatigue, which may obscure important individual differences in the severity and course of fatigue over time. The current study was designed to identify distinct trajectories of fatigue from diagnosis into survivorship in a longitudinal study of women with early-stage breast cancer.
Women with stage 0 to stage IIIA breast cancer (270 women) were recruited before (neo)adjuvant therapy with radiotherapy, chemotherapy, and/or endocrine therapy and completed assessments at baseline; posttreatment; and at 6 months, 12 months, and 18 months of follow-up. Growth mixture modeling was used to identify trajectories of fatigue, and differences among the trajectory groups with regard to demographic, medical, and psychosocial variables were examined.
Five distinct trajectories of fatigue were identified Stable Low (66%), with low levels of fatigue across assessments; Stable Highstress may be at risk of more severe and persistent fatigue.In vivo reflectance confocal microscopy (RCM) findings of lymphangiomas have been scarcely reported. We report a lymphangioma circumscriptum (LC) with some new observations.
Little is known about the pathophysiology of hyperemesis gravidarum (HG). Proposed underlying causes are multifactorial and thyroid function is hypothesized to be causally involved. In this study, we aimed to assess the utility of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) as a marker and predictor for the severity and clinical course of HG.
We conducted a prospective cohort study including women admitted for HG between 5 and 20weeks of gestation in 19 hospitals in the Netherlands. Women with a medical history of thyroid disease were excluded. TSH and FT4 were measured at study entry. To adjust for gestational age, we calculated TSH multiples of the median (MoM). We assessed HG severity at study entry as severity of nausea and vomiting (by the Pregnancy Unique Quantification of Emesis and nausea score), weight change compared with prepregnancy weight, and quality of life. We assessed the clinical course of HG as severity of nausea and vomiting and quality of life 1week after inclusion, durfindings show an inconsistent role for TSH, TSH MoM, or FT4 at time of admission and provide little guidance on the severity and clinical course of HG.
Our findings show an inconsistent role for TSH, TSH MoM, or FT4 at time of admission and provide little guidance on the severity and clinical course of HG.
Certolizumab pegol (CZP), the Fc-free, PEGylated anti-tumor necrosis factor, is approved for the treatment of moderate to severe plaque psoriasis (PSO) in Western countries and in Japan, among other indications.
We report results from the first 16weeks of a 52-week phase2/3 trial of CZP in Japanese patients with PSO. Patients ≥ 20years with PSO ≥ 6months (Psoriasis Area and Severity Index [PASI] ≥ 12, body surface area affected ≥ 10%, and Physician's Global Assessment [PGA] ≥ 3 on a 5-point scale) were randomized 221 to CZP 400mg every 2weeks (Q2W), CZP 200mg Q2W (400mg weeks0/2/4), or placebo Q2W. Outcomes assessed to week16 PASI75, PASI90, PGA0/1 (Markov chain Monte Carlo), Dermatology Life Quality Index (DLQI 0/1) and Itch Numeric Rating Scale (INRS 0) (non-responder imputation), and DLQI and INRS change from baseline (last observation carried forward). Safety data were reported for patients receiving ≥ 1 dose of study medication through weeks0-16; adverse events were evaluated using Medical Dictionary for Regulatory Activities version 18.