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The aim of this review was to synthesize the psychometric properties of generic preference-based measures (PBMs) of health-related quality of life (HRQL) in Amyotrophic Lateral Sclerosis (ALS).
A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Four databases were searched from inception to April 2019 OVID Medline, Embase, PsycINFO, and CINAHL. Studies were included if (1) the sample represented individuals with ALS, (2) a generic PBM was utilized and reported on, and (3) information on the psychometric property of a generic PBM was provided.
Ninety-one articles were screened, and 39 full-text articles were reviewed. Seven full-text articles were included in this review. The mean age of participants ranged from 58.1 to 63.8 years, and mean time since diagnosis ranged from 20.5 to 44.6 months. Two generic PBMs were found, the EQ-5D-3L (
 = 6) and the Quality of Well-Being Self-Administered (QWB-SA) scale (
 = 1). Convergent validity of the EQ-5D-3L was large against a global scale of self-perceived health (
 = 0.60) and small to large against ALS specific HRQL measures (
 = 0.19 to 0.75). read more For the QWB-SA scale, correlations were small against a generic measure (
 = 0.21) and large against ALS specific measures (
 = 0.55). The EQ-5D-3L discriminated across different disease severity; however, floor effects were reported.
This review highlights the need for more rigorously designed studies to assess the psychometric properties of generic PBMs in ALS and the development of an ALS specific PBM that adequately reflects the health concerns of individuals with ALS.
This review highlights the need for more rigorously designed studies to assess the psychometric properties of generic PBMs in ALS and the development of an ALS specific PBM that adequately reflects the health concerns of individuals with ALS.
In a country like India, where the prevalence of tuberculosis is very high, the role of screening tools for detection of latent tuberculosis infection (LTBI) like TST and IGRA is still unclear, especially in inflammatory bowel disease (IBD) patients. Our study is aimed at comparing the interferon-gamma release assay (IGRA) and tuberculin skin test (TST) to determine the prevalence of LTBI in IBD patients in the Indian subset of the population.
It was a prospective observational analysis. A total of 257 participants were included in the study. Both TST and IGRA were performed in consecutive patients diagnosed with IBD (131 patients) and in 126 healthy individuals. Both tests were performed on the same day. LTBI diagnosis was considered if any one of TST or IGRA was found to be positive.
Out of 131 IBD patients, 121 patients had ulcerative colitis and 10 patients had Crohn's disease. 29% of the IBD patients and 22% of the control subjects had LTBI. The study demonstrated concordance between TST and IGRA. Agreement test kappa value for IBD patients was 0.656 (CI 0.50-0.81), with a
value of <0.001, suggestive of a fair agreement. Mean IFN-
release was lower in the immunosuppressed group as compared to non-immunosuppressed individuals (0.26 ± 0.17 vs. 0.45 ± 0.07,
= 0.02). Cohen's kappa coefficient values in IBD cases and control subjects were 0.66 and 0.79, respectively. TST was found to be negatively correlated to BMI.
Agreement between TST and IGRA was fair in IBD patients. For LTBI screening in IBD patients, TST and IGRA are complementary methods.
Agreement between TST and IGRA was fair in IBD patients. For LTBI screening in IBD patients, TST and IGRA are complementary methods.
The assessment to provide care and support to patients with major depressive disorder (MDD) currently focuses on the recovery from the disease, but it is still lacking in measuring and developing psychological well-being among Thai patients with MDD. Therefore, this research is aimed at studying the psychometric properties of the Thai version psychological well-being scale and study factors related to among patients with MDD.
The Thai version psychological well-being scale, an 8-point Likert-type scale, was translated by our research team and used to examine psychometric properties as well as to identify the factors related to psychological well-being in a cross-sectional study among samples of 111 patients diagnosed with MDD from Princess Maha Chakri Sirindhorn Medical Center in Nakhon Nayok Province, Thailand.
Cronbach's alpha for the Thai version psychological well-being scale was .91, unidimensionality was examined with exploratory factor analysis, and the structural validity was assessed with confirmatory factor analysis. The convergent validity was found using the correlation coefficients of the Thai version psychological well-being scale with the Beck Depression Inventory (BDI) and Gratitude Questionnaire (GQ-6). However, none of the social factors were significantly correlated with Thai patients' psychological well-being with MDD.
The Thai version psychological well-being scale is a brief and concise scale with high reliability to evaluate Thai patients with MDD which can support and improve their well-being.
The Thai version psychological well-being scale is a brief and concise scale with high reliability to evaluate Thai patients with MDD which can support and improve their well-being.
Preeclampsia is the second most common problem that causes maternal morbidity and complication in low-income countries. In contrast to death due to other direct causes, preeclampsia-related death is appeared to be connected with multiple factors; yet, factors have paucity and are limited. Considering the clinical significance, this study aimed to identify that individual and obstetric factors of preeclampsia can be an input for disease identification involving clinicians in southern Ethiopia.
A case-control study was conducted among mothers with a singleton pregnancy who attended perinatal care in all six public hospitals in the provinces around the Omo stream. A sample size of 487 women with a singleton pregnancy (163 cases and 326 controls) was involved in the study. All cases were enrolled, while controls were selected consecutively using a random sampling technique. Data were gathered using a structured questionnaire and data extraction sheet. Descriptive data were presented using percentages and numbers.