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hoosing the best treatment for these patients.
With the introduction of new devices and the development of approved devices, endovascular techniques are more and more considered as a treatment option for middle cerebral artery aneurysms (MCA). In this study, we present data on ruptured MCA aneurysms that were treated endovascularly in our hospital.
In a retrospective case series of ruptured MCA bifurcation aneurysms, 118 (94%) cases were managed endovascularly between May 2008 and July 2017. Most were managed with coiling (= 62) and the remaining were managed with stent-assisted-coiling (= 35) and endovascular flow disruptor (WEB-device) (= 21). We measured the clinical outcome at the time of discharge and long-term follow-up on the modified Rankin Scale (mRS) and evaluated the rates of periprocedural complications and retreatment.
A good clinical outcome (mRS 0-2) at discharge was achieved in 58.5% of these cases. Mortality rate was 19.5%. Nine aneurysms required retreatment. Eighty-three percent demonstrated a good clinical outcome at long-term follow-up (mRS 0-2). learn more In total, 6 (5.1%) procedure-related complications and 10 (8.5%) disease-related complications occurred. No significant difference between reintervention, complications or outcome was found between the employment of different devices (P > 0.05). Endovascular treatment of ruptured MCA aneurysms at our practice showed similar morbidity and mortality to data published about surgical clipping.
The endovascular device evolution permits a feasible and safe treatment of ruptured MCA bifurcation aneurysms. Endovascular treatment can therefore be considered as an alternative treatment option to microsurgery for this type of aneurysm.
The endovascular device evolution permits a feasible and safe treatment of ruptured MCA bifurcation aneurysms. Endovascular treatment can therefore be considered as an alternative treatment option to microsurgery for this type of aneurysm.
Currently, there are no recommendations regarding the use of heparinized flush during endovascular thrombectomy (EVT) for acute ischemic stroke. Periprocedural heparin could, however, affect functional outcome and symptomatic intracranial hemorrhage (sICH). We surveyed protocols on heparin flush concentrations in DutchEVT centers and assessed its effect on safety and efficacy outcomes.
Patients registered in theMR CLEAN Registry, from 2014 up to 2017 were included. We collected data on center protocols regarding heparin flush concentrations (IU/L) and grouped patients by their per protocol administered heparin flush concentration. We used a random effects model with random intercepts by EVT center and analyzed endpoints using regression models. Endpoints were sICH, mRS at 90days, mortality and reperfusion rates.
A total of 3157 patients were included of which 45% (6 centers) received no heparin in the flush fluids, 1.8% (1 center) received flush fluids containing 2000IU/L heparin, 26% (4 centers) receivs.The fatty acid composition of bacterial isolates remains stable under standardized culture conditions, which makes it a useful taxonomic marker. The present study aims to characterize the diversity and quantity of fatty acid methyl esters (FAME) profiles of cultivable bacterial isolates collected along the southwest coast of India. Based on the similarity indices (range > 0.3-0.7) of the FAME profiles, the isolates were aggregated into 10 families, 11 genera and 19 species of cultured isolates. The following classes of bacteria were found Bacilli, Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria and Actinobacteria, which also included a few pathogens such as Pseudomonas, Staphylococcus and Bacillus sp. The hydroxyl FAMEs 2-hydroxydodecanoic acid (C120 2OH), 2-hydroxypentadecanoic acid (C150 2OH),3-hydroxy 14-methylpentadecanoic acid (C160iso 3OH), 3 hydroxy hexadecenoic acid (C160 3OH) and 3-hydroxy 15-methylhexadecanoic acid (C170iso 3OH), as well as the unsaturated FAMEs (11Z)-11-hexadecenoic acid (C161 ɷ5c), were exclusively associated with the isolates from Mangalore samples. Similarly, FAMEs 2-hydroxydecanoic acid (C100 2OH), 9-methyldecanoic acid (C110iso), undecanoic acid (C110), tridecanoic acid (C130), 10-methylhexadecanoic acid (C160 10-CH3) and (7Z)-7-hexadecenoic acid (C161 ɷ9c) occurred only in the isolates from Trivandrum samples. However, the isolates from Goa did not possess a signature FAME profile. The reproducibility of the GC-MIDI bacterial identification system was evaluated using 16S rRNA gene sequencing techniques for selected isolates.A novel bacterial strain, designated 17J68-15T, was isolated from dry soil collected in Jeju Island, South Korea. Cells of strain 17J68-15T are Gram-negative, pale-yellow-colored, non-motile, non-spore-forming, rod-shaped was able to grow at 18-42 °C with 0-1% NaCl on R2A agar. Phylogenetic analysis based on the 16S rRNA gene sequence revealed that the strain was distinct from any previously known species of the genus Flaviaesturariibacter. The highest degrees of 16S rRNA gene sequence similarity found with Flaviaesturariibacter terrae HY03T (97.6%), Flaviaesturariibacter amylovorans (96.2%) and Flaviaesturariibacter luteus AW305T (96.0%). The DNA G + C content of the novel strain, 17J68-15T, was 9.3 mol%. Chemotaxonomic data revealed that the major fatty acids were iso-C150, iso-C151 G, iso-C170 3-OH and summed feature 3 (C161 ω6c and/or C161 ω7c); the major polar lipid was identified as phosphatidylethanolamine, and the major quinone was identified as MK-7. Based on polyphasic characterization, strain 17J68-15T represents a novel species of the genus Flaviaesturariibacter for which the name Flaviaesturariibacter aridisoli sp. nov. is proposed, with the type strain 17J68-15T (= KCTC 62220T = JCM 19635T).The chitinases are gaining much attention based on their role in the defense against pathogen attacks and harmful insects. The partially chitinase produced by Bacillus licheniformis strain J24 exhibited a large antifungal spectrum, and the highest activity was obtained toward Fusarium species in vitro on PDA and in vivo on corn seeds. The chitinase was inducible by the presence of autoclaved Fusarium conidia in the medium culture and it was active at 70 °C and pH 7 and not affected by the tested chemical agents EDTA and SDS. The nucleotide and amino acid sequences encoding chitinase showed the close phylogenetic relation with chitinase from Bacillus paralicheniformis species. Based on the analysis of the putative domain active, the described chitinase from strain J24 was belonging to the GH family-18 and the novelty of its structure was revealed. Here the combination of functional and structural antifungal extremely chitinase proves its importance in biotechnology area.