Main visible cortex straightens organic movie trajectories

Among those, ammonia, H2S, phenol, toluene and trimethylamine, produce an odor stimulus before they reach a toxic concentration, thus not representing a risk for olfactometric workers. Benzene, formaldehyde and SO2 are identified as the most critical compounds because they may reach toxic concentrations in foundry emissions, and they start being perceived by humans above their TLV. The proposed procedure entails a minimum dilution factor of 27'000 to be applied to odor samples analyzed by olfactometry, which however might result inapplicable in practical cases, thus pointing out the necessity to adopt chemical measurements to investigate specifically the concentration of the most critical compounds identified in this study.In the biomedical, behavioral and neurobiological sciences reproducibility and replicability of research results have become a major issue. The question is whether attachment research is also plagued by lack of replicability, and if so whether one can speak of a crisis? Furthermore, discussions about the applicability of attachment research findings to policy and (clinical) practice have recently been intensified. The subsequent question arises whether one could even speak of a "translational crisis". In this paper assumptions and conditions of replicability and applicability will be outlined. Some examples of attachment findings lost or found in translation to policy and practice (e.g. on infant crying and parental insensitive responsiveness) will be used to illustrate the challenges and chances of bridging the gap between attachment science and practice.Diabetes mellitus is a chronic metabolic disorder with multiple complications, patients who receive metformin may have a simultaneous intake of herbal medicine containing rutaecarpine due to cardiovascular protection and hypolipidemic effects of rutaecarpine. There might be drug interactions between metformin and rutaecarpine. This study aimed to investigate the effects of rutaecarpine on the pharmacodynamics and pharmacokinetics of metformin in diabetic rats.The diabetic rat model was induced with high-fat diet and low dose streptozotocin. Metformin with or without rutaecarpine was administered by oral gavage for 42 days. Pharmacodynamics and pharmacokinetics parameters were evaluated.The pharmacodynamics results revealed that co-administration of rutaecarpine with metformin resulted in a remarkable reduction of serum glucose and lipid profiles in diabetic rats compared to metformin treated alone. The pharmacokinetics results showed that co-treatments of rutaecarpine with metformin did not affect the systemic exposure and renal distribution of metformin, but increased metformin concentration in liver. Furthermore, rutaecarpine increased Oct1-mediated metformin uptake into hepatocytes by upregulation of Oct1 expression in the liver.The above data indicate that rutaecarpine enhanced the anti-diabetic effect of metformin, which may be associated with the increased hepatic distribution of metformin through up-regulation of Oct1 in response to rutaecarpine.Although there are several treatments for rheumatoid arthritis (RA), outcomes are unsatisfactory and often associated with many side effects. We attempted to improve RA therapeutic outcomes by intra-articular administration of dual drug-loaded poly(lactic) acid (PLA)-coated herbal colloidal carriers (HCCs). Curcumin (CU) and resveratrol (RES) were loaded into HCCs because of their safety and significant anti-inflammatory activity. HCCs were prepared using a high-pressure, hot homogenization technique and evaluated in vitro and in vivo using a complete Freund's adjuvant-induced arthritis model. Transmission electron microscope (TEM) evaluated coating selected formulations with PLA, which increased particle sizes from 52 to 89.14 nm. The entrapment efficiency of both formulations was approximately 76%. HCCs significantly increased the amount of RES and CU released compared with the drug suspensions alone. The in vivo treated groups showed a significant improvement in joint healing. PLA-coated HCCs, followed by uncoated HCCs, yielded the highest reductions in knee diameter, myeloperoxidase (MPO) levels, and tumor necrosis factor-alpha (TNFα) levels. Histological examination of the dissected joints revealed that PLA-coated HCCs followed by uncoated HCCs exhibited the most significant joint healing effects. Our results demonstrate the superiority of intra-articularly administered HCCs to suppress RA progression compared with RES or CU suspensions alone.Jean Laplanche's interest in psychosis dates back to at least the early 1960s, that is to say, the period of his cooperation with Lacan. As Laplanche's thought developed towards the general theory of seduction, which was his most significant theoretical achievement, the conceptualization of the aetiology and symptomatology of psychosis became increasingly complex. The paper aims to present crucial elements of the Laplanchian theory of psychosis, such as the role of sexual reality and ego-agency, the concept of intromission and implantation, and finally the concept of the radical failure of translation. The last part of the article is devoted to the possibility of psychoanalytic or psychoanalysis-inspired treatment of psychosis. In addition, a modified topography model proposed by Laplanche is presented. A "unified theory of the apparatus of the soul" - as Laplanche calls his topography - is an attempt to reconcile the theory of psychosis with the general model of psychic apparatus.Translation of psychoanalytic texts is notoriously complex, amplified by differences between Western languages/cultures and China. Freud labelled translation "traitorous". this website A current challenge is the trend among some professional translators to diminish or eliminate hierarchies of accurate and inaccurate translations. We argue for accurate translation to transmit psychoanalytic concepts in Mandarin Chinese. The English Standard Edition involved unfortunate choices to "Latinize" key Freudian terms; for example, Es, Ich and Überich were rendered as Id, Ego and Supergo, instead of more experience-near common language equivalents in English, "it, I and over I." Similarly, some recent translations of German and English psychoanalytic terms into Mandarin Chinese have also tended to perpetuate intellectualized distancing from Freud's original vivid words. Here, we focus on seven critical terms for core psychoanalytic concepts Ich/I, Es/it, Überich/superego, Transference (Übertragung), Countertransference (Gegenübertragung), Psyche/Soul (Psyche/Seele), psychoanalysis and (surprisingly) schizophrenia. We suggest that the currently popular oral-aural translations from English into Mandarin perpetuate distancing and lead to mis-translations that obscure our foundational concepts. We propose alternative Mandarin translations for some terms and discuss the broader cultural challenges involved in transmitting the heart (and soul) of psychoanalysis with Chinese colleagues.This article addresses the tense relationship between Sigmund Freud's thinking and the materialist perspective of history. It presents a theoretical contribution that emerges from this dialogue and thoughtfully considers its contradictions. First, I synthesise Freud's critiques of historical materialism, with the issue of psychic temporality occupying a key role. I then address the work of Walter Benjamin, who, in my view, has managed to fruitfully integrate a good part of Freud's insights into the construction of a peculiar heterodox materialism that I call multitemporal. I support this claim in two ways (a) I demonstrate the relevance of psychoanalysis as an indispensable source of nourishment for Benjamin's thought; and (b) I identify a shared heritage (with Nietzsche) and some parallels between Freudian thought and Benjaminian materialism with respect to their conceptions of time, history, and unconscious memory, as well as the key differences that both distinguish them and enable them to question one another. I conclude by pointing out that, if we reflect upon what may be its theological impediments in a critical-that is, irreligious or metapsychological-light, Benjamin's thought can provide a way to explore the contributions of psychoanalysis to critical social theory.The paper gives a survey of the origin of the concept of the super-ego in Freud's work and its further elaboration within the different psychoanalytic traditions. It introduces three papers on the perverse and psychotic super-ego, the development of the concept in Bion's work and its significance for psychoanalytic social psychology.In recent years, a growing acknowledgement of the importance and originality of Sabina Spielrein's theoretical and clinical work has taken place. However, few studies have been specifically devoted to a thorough analysis of her theory, so a satisfactory understanding of her thinking has not yet been fully achieved. The objective of this article is to contribute to the understanding of Spielrein's theory of language, based on the analysis of her two main papers on the subject, "The Origin of the Child's Words 'Papa' and 'Mama'" (1922) and "Some Analogies between the Thought of Children, Aphasia, and the Subconscious Thought" (1923). Reference is also made to some hypotheses formulated in her first works in order to clarify the assumptions of the theory of language she advances in the early 1920s. It is argued that Spielrein developed an original psychoanalytic perspective on language. She brought about an innovative contribution to the understanding of the origins and functioning of both language and thought, articulating linguistic and neurological knowledge with psychoanalytic hypotheses and her own observations.In this contribution I will sustain that, given its origin, meaning and function, the superego is readily susceptible to the pathological distortions observed in clinical psychoanalytic work. After all, while we as psychoanalysts are unacquainted with the "normal" superego, we are accustomed to seeing patients with either an abnormal sense of guilt or a seeming absence of guilt. However, a distinction must first be drawn between the primitive superego and its pathological counterpart. Whereas some clinical situations involve a superego whose primitive aspects feature prominently in the foreground, in other cases one encounters psychopathological structures that do not stem from the primitive superego, even if they share the latter's seductive, dominant or intimidatory aspects.This paper provides a historical overview of the reception of the superego concept in sociology and psychoanalytic social psychology. Central to the discussion are the ways in which classical and contemporary approaches (e.g. Parsons, Elias, Bourdieu) have responded to Freud's theories concerning the genesis of the superego and its changes in the course of psychic development, to his suppositions concerning anthropology and psychopathology, and to later psychoanalytic extensions of the concept (e.g. Klein, Erikson and Loewald). With reference to Freud's works of cultural critique, special emphasis is given to conceptions of the superego in studies on authoritarianism, adaptation and morality, notably by the Frankfurt School (Fromm, Horkheimer, Adorno). The authors also discuss the historical changes undergone by the superego concept and examine by way of examples the benefits of concept for achieving a clearer understanding of recent societal trends associated with contemporary phenomena such as digitization and optimization.