Motivation behind operating amid elderly mature runners

Sugarcane Distillery Spent Wash (DSW) is among the most pollutant industrial effluents, generally characterized by high Chemical Oxygen Demand (COD), high mineral matters and acidic pH, causing strong environmental impacts. Bioremediation is considered to be a good and cheap alternative to DSW treatment. In this study, 37 strains of yeasts and filamentous fungi were performed to assess their potential to significantly reduce four parameters characterizing the organic load of vinasses (COD, pH, minerals and OD475nm). In all cases, a pH increase (until a final pH higher than 8.5, being an increase superior to 3.5 units, as compared to initial pH) and a COD and minerals removal could be observed, respectively (until 76.53% using Aspergillus terreus var. africanus and 77.57% using Aspergillus niger). #link# Depending on the microorganism, the OD475nm could decrease (generally when filamentous fungi were used) or increase (generally when yeasts were used). Among the strains tested, the species from Aspergillus and Trametes genus offered the best results in the depollution of DSW. Concomitant with the pollutant load removal, fungal biomass, with yields exceeding 20 g·L-1, was produced.Concrete exhibits a complex mechanical behavior, especially when approaching failure. Its behavior is governed by the interaction of the heterogeneous structures of the material at the first level of observation below the homogeneous continuum, i.e., at the mesoscale. Concrete is assumed to be a three-phase composite of coarse aggregates, mortar, and the interfacial transitional zone (ITZ) between them. Finite element modeling on a mesoscale requires appropriate meshes that discretize the three concrete components. As the weakest link in concrete, ITZ plays an important role. However, meshing ITZ is a challenging issue, due to its very reduced thickness. Representing ITZ with solid elements of such reduced size would produce very expensive finite element meshes. An alternative is to represent ITZ as zero-thickness interface elements. This work adopts interface elements for ITZ. Damage plasticity model is adopted to describe the softening behavior of mortar in compression, while cohesive fractures describe the cracking process. Numerical experiments are presented. First example deals with the estimation of concrete Young's modulus. Experimental tests were performed to support the numerical test. A second experiment simulates a uniaxial compression test and last experiment simulates a uniaxial tensile test, where results are compared to data from the literature.Targeting endothelial cell (EC) metabolism should impair angiogenesis, regardless of how many angiogenic signals are present. The dependency of proliferating ECs on glucose and glutamine for energy and biomass production opens new opportunities for anti-angiogenic therapy in cancer. The aim of the present study was to investigate the role of pyruvate dehydrogenase kinase (PDK) inhibition with dichloroacetate (DCA), alone or in combination with the glutaminase-1 (GLS-1) inhibitor, Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl) ethyl sulfide (BPTES), on Human umbilical vein endothelial cells (HUVECs) metabolism, proliferation, apoptosis, migration, and vessel formation. We demonstrated that both drugs normalize HUVECs metabolism by decreasing glycolysis for DCA and by reducing glutamate production for BPTES. ML141 in vitro and BPTES reduced HUVECs proliferation and migration but have no impact on tube formation. While DCA increased HUVECs respiration, BPTES decreased it. Using both drugs in combination further reduced HUVECs proliferation while normalizing respiration and apoptosis induction. Overall, we demonstrated that DCA, a metabolic drug under study to target cancer cells metabolism, also affects tumor angiogenesis. Combining DCA and BPTES may reduce adverse effect of each drug alone and favor tumor angiogenesis normalization.Sensors are excellent options owing to their ability to figure out a large number of problems and challenges in several areas, including homeland security, defense, medicine, pharmacology, industry, environment, agriculture, food safety, and so on. Plasmonic sensors are used as detection devices that have important properties, such as rapid recognition, real-time analysis, no need labels, sensitive and selective sensing, portability, and, more importantly, simplicity in identifying target analytes. This review summarizes the state-of-art molecular recognition of biological and chemical threat agents. For this purpose, the principle of the plasmonic sensor is briefly explained and then the use of plasmonic sensors in the monitoring of a broad range of biological and chemical threat agents is extensively discussed with different types of threats according to the latest literature. A conclusion and future perspectives are added at the end of the review.Dynamic interactions between gut microbiota and a host's innate and adaptive immune systems play key roles in maintaining intestinal homeostasis and inhibiting inflammation. The gut microbiota metabolizes proteins and complex carbohydrates, synthesize vitamins, and produce an enormous number of metabolic products that can mediate cross-talk between gut epithelial and immune cells. As a defense mechanism, gut epithelial cells produce a mucosal barrier to segregate microbiota from host immune cells and reduce intestinal permeability. An impaired interaction between gut microbiota and the mucosal immune system can lead to an increased abundance of potentially pathogenic gram-negative bacteria and their associated metabolic changes, disrupting the epithelial barrier and increasing susceptibility to infections. Gut dysbiosis, or negative alterations in gut microbial composition, can also dysregulate immune responses, causing inflammation, oxidative stress, and insulin resistance. Over time, chronic dysbiosis and the translocation of bacteria and their metabolic products across the mucosal barrier may increase prevalence of type 2 diabetes, cardiovascular disease, inflammatory bowel disease, autoimmune disease, and a variety of cancers. In this paper, we highlight the pivotal role gut microbiota and their metabolites (short-chain fatty acids (SCFAs)) play in mucosal immunity.