TimeCourse Transcriptome Profiling of a Poxvirus Using LongRead FullLength Analysis

These inconsistencies were most pronounced in the mildest stages of impairment. For a subset of the sample, rates of patients reporting depressive symptoms when informants denied observing the same also increased alongside worsening impairment. Incremental impairment in episodic learning (χ² = 805.25) and memory (χ² = 856.94) performance were most closely associated with decreases in respondent agreement. Patient-informant relationship type did not appear to mediate the response patterns observed. CONCLUSIONS Mild impairment in AD patients, particularly in episodic learning and memory functioning, is significantly associated with decreases in patient-informant agreement regarding the presence of depressive symptoms. These results suggest that even at the earliest stages of AD informant reports should be used to corroborate patients' reporting. (PsycINFO Database Record (c) 2020 APA, all rights reserved).We investigated 4- and 5-year-olds' (N = 194) appreciation of the link between knowledge and ownership. Namely, we asked whether preschoolers appreciate the ways in which owners are typically knowledgeable about artifacts. Experiment 1 revealed that 4- and 5-year-olds view owners as better sources of knowledge about artifacts than those who simply like artifacts. Experiment 2 built on these findings by showing that 5-year-olds appreciate that owners typically have deep knowledge about artifacts and that they can use this appreciation to guide inferences about who owns what. selleck chemical These experiments are some of the first to investigate how children's inferences about knowledge and ownership are intertwined. As such, they have implications for our understanding of early childhood cognition. First, they provide insights into how object-person relations influence judgments of expertise. Second, they extend current understandings of ownership by demonstrating that ownership influences preschoolers' reasoning in other domains (i.e., knowledge) and by showing that preschoolers' theories of ownership extend beyond normative considerations (i.e., ownership rights). Together, these findings lay the groundwork for a new area of work on how ownership influences children's reasoning about knowledge. (PsycINFO Database Record (c) 2020 APA, all rights reserved).The aim of this longitudinal study was to examine the association of infant fussing and crying with self-regulation in toddlerhood and the preschool years, as well as the moderating role of maternal sensitivity therein. When children (n = 149, 53.69% boys) were 6 months old, parents reported on their fussing and crying using a cry diary, and maternal sensitivity was coded during a novel toy procedure. Children participated in various tasks to assess self-regulation in toddlerhood (18 months) and the preschool years (4.5 years). Results indicated that the relation between infant fussing and preschool self-regulation took the shape of an inverted U, but only for children of highly sensitive mothers. For infants of less sensitive mothers, fussing was not related to later self-regulation. Crying was unrelated to preschool self-regulation. Neither fussing, crying, nor maternal sensitivity predicted self-regulation in toddlerhood. The findings support the optimal arousal theory, by demonstrating that for infants of highly sensitive mothers, moderate amounts of low intensity negative reactivity are associated with enhanced self-regulation in the preschool years. (PsycINFO Database Record (c) 2020 APA, all rights reserved).When threatened with ostracism, children attempt to strengthen social relationships by engaging in affiliative behaviors such as imitation. We investigated whether an experience of ostracism influenced the extent to which children imitated a partner's language use. In two experiments, 7- to 12-year-old children either experienced ostracism or did not experience ostracism in a virtual ball-throwing game before playing a picture-matching game with a partner. We measured children's tendency to imitate, or align with, their partner's language choices during the picture-matching game. Children showed a strong tendency to spontaneously align with their partner's lexical and grammatical choices. Crucially, their likelihood of lexical alignment was modulated by whether they had experienced ostracism. We found no effect of ostracism on syntactic alignment. These findings offer the first demonstration that ostracism selectively influences children's language use. They highlight the role of social-affective factors in children's communicative development, and show that the link between ostracism and imitation is broadly based, and extends beyond motor behaviors to the domain of language. (PsycINFO Database Record (c) 2020 APA, all rights reserved).This study examined the effects of food insecurity and housing instability experiences during early childhood on adolescent anxiety and depressive symptoms through maternal depression and parenting stress. This longitudinal study included 4 waves of data from the Fragile Families and Child Well-Being Study (n = 2,626). Food insecurity was measured when the child was 5 years of age using the U.S. Department of Agriculture's 18-item Food Security Scale. Housing instability was also measured when the child was 5 years of age based on an affirmative response to 6 housing adversity items. Maternal depression and parenting stress were measured when the child was 9 years of age. Anxiety and depressive symptoms were assessed when the child (now adolescent) was 15 years of age using 6 items of the Brief Symptom Inventory 18 anxiety subscale and 5 items of the Centers for Epidemiologic Studies Depression Scale, respectively. Two structural equation models assessed the associations between food insecurity and housing instability on adolescent anxiety (Model 1) and depressive symptoms (Model 2) through maternal depression and parenting stress simultaneously, controlling for sociodemographic characteristics. Results suggest that experiencing both food insecurity and housing instability during early childhood increases the risk of long-term adolescent depressive (indirect B = 0.008, 95% CI [0.002, 0.016]) and anxiety (indirect B = 0.012, 95% CI [0.002, 0.026]) symptoms through maternal depression to parenting stress. Screening for food insecurity and housing instability during early childhood could potentially identify both mothers who are at risk for depression and parenting stress and children who are at increased risk for anxiety or depressive symptoms during adolescence. (PsycINFO Database Record (c) 2020 APA, all rights reserved).